- Author:
- Weiwei Ai <wai484@aucklanduni.ac.nz>
- Date:
- 2024-03-25 13:29:39+13:00
- Desc:
- Add params_BG_fit.cellml to capture the parameter constraints based on kinetic data
- Permanent Source URI:
- https://models.physiomeproject.org/workspace/b65/rawfile/57b78f0511ef662b78925ad4f6e35f856fb980b7/Facilitated transporter/GLUT1_kinetic.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="GLUT1_kinetic" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
<!-- Facilitated diffusion -->
<units name="mM">
<unit prefix="milli" units="mole"/>
<unit exponent="-1" units="liter"/>
</units>
<units name="mM_per_s">
<unit units="mM"/>
<unit exponent="-1" units="second"/>
</units>
<component name="main">
<variable name="t" units="second"/>
<variable initial_value="1.64" name="K_io" units="mM"/>
<variable initial_value="0.0713" name="V_io" units="mM_per_s"/>
<variable name="v_io_ss" units="mM_per_s"/>
<variable initial_value="0.145" name="K_oi" units="mM"/>
<variable initial_value="0.00548" name="V_oi" units="mM_per_s"/>
<variable name="v_oi_ss" units="mM_per_s"/>
<variable initial_value="0" name="g" units="mM"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>t</ci>
</bvar>
<ci>g</ci>
</apply>
<cn cellml:units="mM_per_s">1</cn>
</apply>
<apply>
<eq/>
<ci>v_io_ss</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_io</ci>
<ci>g</ci>
</apply>
<apply>
<plus/>
<ci>K_io</ci>
<ci>g</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>v_oi_ss</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>V_oi</ci>
<ci>g</ci>
</apply>
<apply>
<plus/>
<ci>K_oi</ci>
<ci>g</ci>
</apply>
</apply>
</apply>
</math>
</component>
</model>
